Global Stability of McKeithan's Kinetic Proofreading Model for T-Cell Receptor Signal Transduction
نویسنده
چکیده
This note presents a self-contained and streamlined exposition of chemical-network results due to Feinberg, Horn, and Jackson. As an application, it shows the global asymptotic stability to equilibria of McKeithan’s kinetic proofreading model for T-cell receptor signal transduction.
منابع مشابه
Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction
This paper deals with the theory of structure, stability, robustness, and stabilization for an appealing class of nonlinear systems which arises in the analysis of chemical networks. The results given here extend, but are also heavily based upon, certain previous work by Feinberg, Horn, and Jackson, of which a self-contained and streamlined exposition is included. The theoretical conclusions ar...
متن کاملKinetic proofreading in T-cell receptor signal transduction.
Like other cell-surface receptors with intrinsic or associated protein-tyrosine kinase activity, the T-cell receptor complex undergoes a number of modifications, including tyrosine phosphorylation steps, after ligand binding but before transmitting a signal. The requirement for these modifications introduces a temporal lag between ligand binding and receptor signaling. A model for the T-cell re...
متن کاملKinetic Proofreading of Ligand-Fc!RI Interactions May Persist beyond LAT Phosphorylation
Cells may discriminate among ligands with different dwell times for receptor binding through a mechanism called kinetic proofreading in which the formation of an activated receptor complex requires a progression of events that is aborted if the ligand dissociates before completion. This mechanism explains how, at equivalent levels of receptor occupancy, a rapidly dissociating ligand can be less...
متن کاملRecent Advances in T Cell Signaling in Aging
The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
متن کاملSignaling Efficiency of Kinetic Proofreading in T-cells
We apply information theoretic and energetic constraints to a key problem in cell signaling. While the cell signaling modeling process generally starts with assumptions about the system’s structure, additional assumptions about the system’s performance objectives can be used to compensate for insufficient data. In our work, we obtain parameters for a model of signal transduction across a T-cell...
متن کامل